Biology 104 Spring 2005

Biology 104 Vertebrate Embryology Spring 2005

Albert Harris

Textbook "Developmental Biology" Scott Gilbert SEVENTH EDITION

Lectures Mon-Wed-Fri 9-9:50 Harris Office Hours: MWF 10-12; Friday 2-5 akharris@med.unc.edu

Harris Office room 104 Wilson Hall, Tel.966-1230
Home phone (But please don't call me at home unless you really need to) 493-1572 (Durham)

Brian Dewar: Office 936 Mary-Ellen Jones Building brian_dewar@med.unc.edu 966-0916 (ask for Brian)

1) Wed Jan 12: What happens in development; fertilization, cleavage, differentiation, rearrangements pp 3-8, web page

2) Fri Jan 14 Compare embryology of sea urchin, frog, bird & mammal; similarities & differences pp 9-16

Mon. Jan 17 Holiday in honor of Rev Martin Luther King jr.

3) Wed Jan 19 Mathematical theories about the control of anatomical pattern formation pp.8-22, and pages 64-69, web page on Turing

4) Fri Jan 21 Unicellular organisms --> Multicellular organisms read pages 33-38

5) Mon. Jan 24 Dictyostelium (slime molds: another example of 1-cell->many cell read pp 39-44, web page

6) Wed Jan. 26 The molecular genetic approach to embryology Chapter Four pages 81-106, web page

7) Fri. Jan. 28 Mechanisms of differential gene expression Chapter Five pp. 107-142, web page

8) Mon Jan. 31 Differential gene expression

9) Wed Feb 2 Why do dissociated cells sort out & reform tissues?
What is its biological significance? pp 70-77, web page

10) Fri. Feb 4 Control of gene expression lecture notes, "Magic House", review questions

11) Mon Feb. 7 First Exam

12) Wed Feb. 9 All the cells contain all the genes/ the evidence & exceptions/ immunity & autoimmune disease

13) Fri Feb. 11 Control of gene expression by cell-cell signals:="embryological induction" Chap. Six pp 143-180, web page

14) Mon Feb. 14 Fertilization: Chapter 7 183-219, web page

15) Wed Feb. 16 * Symmetry, different kinds of symmetry, Curie's law as applied to animal development web page revised 2/22/05

16) Fri Feb.18 * Mechanical forces, vectors, tensors, curvature and how these are related to embryology web page revised 2/22/05

17) Mon Feb.21 Cleavage and axis development in frog and salamander embryos. Chapter Ten

18) Wed Feb. 23 Early development of teleost fish, reptiles, birds and mammals. Chapter Eleven, web page

19) Fri Feb. 25 * Specific facts about human embryonic and fetal development web page, (xeroxed handout)

20) Mon Feb. 28 How genes control fly embryology web page, Chapter 9

review questions

21) Wed Mar. 2 Second Exam

22) Fri Mar. 4 Development of ectodermal organs Chapter 12, web page

23) Mon Mar.7 Neural crest pp 427-442, web page

24) Wed Mar. 9 Development of plants, as an interesting contrast to animal embryos Chapter 20 pp 649-681, web page

25) Fri Mar. 11 More on development of higher plants

Mon. Mar 14 Spring vacation Wed. Mar 16 Fri. Mar 18

26) Mon Mar. 21 What mechanisms control the proper "wiring" of the nervous system? pp. 442-463

27) Wed Mar. 23 More on the wiring of the nervous system, especially eye to brain connections. web page

Fri. Mar. 25 Good Friday Holiday

28) Mon Mar. 28 Mesoderm: Notochord, Somites and Intermediate Mesoderm Chapter 14 pages 465-489

29) Wed Mar. 30 Lateral plate mesoderm, coelom, uterus and heart Chapter 15 491-509??

30) Fri April 1 Endodermal organs Pages 510-515, web page

31) Mon April 4 Extraembryonic membranes pages 516-517, web page

32) Wed April 6 Legs, wings, arms, maybe even fins Chapter 16 pp 523-546

33) Fri April 8 Review for third exam web page

review questions

34) Mon Apr. 11 Third Exam

35) Wed Apr.13 Sex determination (=mechanisms that cause tissues to become male or female) pp 547-573

36) Fri Apr.15 Metamorphosis (tadpole --> frog, caterpillar->butterfly, maggot -> fly) pp 575-592

37) Mon Apr. 18 Regeneration (why can salamanders regenerate legs, & we regenerate liver? pp 592-601

38) Wed Apr. 20 Aging (maybe it's programmed self-destruction, instead of wearing out? pp 601-606

39) Fri Apr. 22 Primordial germ cells and germ plasm Pages 613-646

40) Mon Apr.25 Medical aspects of embryonic development Chapter 21 pp. 683-719

41) Wed Apr.27 Environmental effects on embryonic development Chapter 22 pp 721-749

42) Fri Apr. 29 "Evo-Devo" = Evolution of developmental mechanisms Chapter 22 pp 721-749

Fri. May 6 8:00 AM Final Exam


1) Wed Jan 12:	What happens in development; fertilization, cleavage, differentiation, rearrangements	pp 3-8, web page
2) Fri Jan 14	Compare embryology of sea urchin, frog, bird & mammal; similarities & differences	pp 9-16

Mon. Jan 17	Holiday in honor of Rev Martin Luther King jr.

3) Wed Jan 19	Mathematical theories about the control of anatomical pattern formation	pp.8-22, and pages 64-69, web page on Turing
4) Fri Jan 21	Unicellular organisms --> Multicellular organisms	read pages 33-38
5) Mon. Jan 24	Dictyostelium (slime molds: another example of 1-cell->many cell	read pp 39-44, web page
6) Wed Jan. 26	The molecular genetic approach to embryology	Chapter Four pages 81-106, web page
7) Fri. Jan. 28	Mechanisms of differential gene expression	Chapter Five pp. 107-142, web page
8) Mon Jan. 31	Differential gene expression
9) Wed Feb 2	Why do dissociated cells sort out & reform tissues? What is its biological significance?	pp 70-77, web page
10) Fri. Feb 4	Control of gene expression	lecture notes, "Magic House", review questions

11) Mon Feb. 7	First Exam

12) Wed Feb. 9	All the cells contain all the genes/ the evidence & exceptions/ immunity & autoimmune disease
13) Fri Feb. 11	Control of gene expression by cell-cell signals:="embryological induction"	Chap. Six pp 143-180, web page
14) Mon Feb. 14	Fertilization:	Chapter 7 183-219, web page
15) Wed Feb. 16	* Symmetry, different kinds of symmetry, Curie's law as applied to animal development	web page revised 2/22/05
16) Fri Feb.18	* Mechanical forces, vectors, tensors, curvature and how these are related to embryology	web page revised 2/22/05
17) Mon Feb.21	Cleavage and axis development in frog and salamander embryos.	Chapter Ten
18) Wed Feb. 23	Early development of teleost fish, reptiles, birds and mammals.	Chapter Eleven, web page
19) Fri Feb. 25	* Specific facts about human embryonic and fetal development	web page, (xeroxed handout)
20) Mon Feb. 28	How genes control fly embryology	web page, Chapter 9

	review questions

21) Wed Mar. 2	Second Exam

22) Fri Mar. 4	Development of ectodermal organs	Chapter 12, web page
23) Mon Mar.7	Neural crest	pp 427-442, web page
24) Wed Mar. 9	Development of plants, as an interesting contrast to animal embryos	Chapter 20 pp 649-681, web page
25) Fri Mar. 11	More on development of higher plants

Mon. Mar 14	Spring vacation Wed. Mar 16 Fri. Mar 18

26) Mon Mar. 21	What mechanisms control the proper "wiring" of the nervous system?	pp. 442-463
27) Wed Mar. 23	More on the wiring of the nervous system, especially eye to brain connections.	web page

Fri. Mar. 25	Good Friday Holiday

28) Mon Mar. 28	Mesoderm: Notochord, Somites and Intermediate Mesoderm	Chapter 14 pages 465-489
29) Wed Mar. 30	Lateral plate mesoderm, coelom, uterus and heart	Chapter 15 491-509??
30) Fri April 1	Endodermal organs	Pages 510-515, web page
31) Mon April 4	Extraembryonic membranes	pages 516-517, web page
32) Wed April 6	Legs, wings, arms, maybe even fins	Chapter 16 pp 523-546
33) Fri April 8	Review for third exam	web page

	review questions

34) Mon Apr. 11	Third Exam

35) Wed Apr.13	Sex determination (=mechanisms that cause tissues to become male or female)	pp 547-573
36) Fri Apr.15	Metamorphosis (tadpole --> frog, caterpillar->butterfly, maggot -> fly)	pp 575-592
37) Mon Apr. 18	Regeneration (why can salamanders regenerate legs, & we regenerate liver?	pp 592-601
38) Wed Apr. 20	Aging (maybe it's programmed self-destruction, instead of wearing out?	pp 601-606
39) Fri Apr. 22	Primordial germ cells and germ plasm	Pages 613-646
40) Mon Apr.25	Medical aspects of embryonic development	Chapter 21 pp. 683-719
41) Wed Apr.27	Environmental effects on embryonic development	Chapter 22 pp 721-749
42) Fri Apr. 29	"Evo-Devo" = Evolution of developmental mechanisms	Chapter 22 pp 721-749
Fri. May 6	8:00 AM Final Exam