| "Interference between two specific pathogen recognition events mediated by distinct plant disease resistance genes." |
| Plant Cell 8, 251-257 |
| Ritter, C and JL Dangl |
| Summary "We demonstrate that the interaction of the avirulence gene avrRpf2 and the cognate resistance gene RPS2 interferes with the interaction of avrRpm7-RPM7 in Arabidopsis. Interference is mediated outside of the bacterial pathogen Pseudomonas syringae, presumably at the leve1 of recognition of avr-dependent signals, yet does not require the wildtype RPSP product. A numerical excess of P. syringae expressing avrRpm7 can overcome this interference in mixed inoculations. The interference of avrRpf2-RPS2 engagement with RPM7-dependent functions is mirrored by transcriptional activation of genes preferentially expressed during RPM7- or RPS2-mediated disease resistance reactions. This demonstration of interference between two plant disease resistance genes suggests that their products compete for a common element(s) in a signal transduction pathway leading to disease resistance. " |