Freddy Monteiro

Email Freddy





2009-2013      Ph.D. Degree: Genetics. Departament de Genètica. Fac. Biologia. Universitat de Barcelona. Barcelona, Spain. Ph.D advisor: Dr. Marc Valls.

2008-2009     M.Sc. Degree: Developmental Biology and Genetics. Departament de Genètica. Fac. Biologia. Universitat de Barcelona. Barcelona, Spain.

2003-2008     B.Sc. Degree: Biochemistry. Faculdade de Ciências e Tecnologia. Universidade de Coimbra. Coimbra, Portugal.

Project Description:

My current interests are focused on understanding how evolutionary diverse plant pathogens evolved independent effector proteins to interact with a limited set of host proteins. For that our group takes advantage of the effector convergence of naturally-occurring pathogens of Arabidopsis, namely, P. syringae (Eubacteria), H. arabidopsidis (Stramenopiles) and G. orontii (Ascomycete), onto a family of plant-specific transcription factors known as TCP [1,2]. These transcription factors are known for their roles in plant development, but a growing body of evidences suggest their contribution in immune processes [2,3,4].

Besides, I am interested in understanding how rapidly plants are overcoming the selective pressure imposed by contemporary pathogens. For that, I am focusing on a pair of divergently transcribed resistance genes present in some Arabidopsis ecotypes and Brassicaceae species. I take advantage of in silico methods to infer allele prevalence, diversity and expression, based on publicly available genomic and transcriptomic datasets. I am also applying molecular biology, biochemistry and plant pathology techniques to characterize the function and the activation mechanism of these genes. This work is part of a collaboration between Prof. Jeff Dangl and Prof. Jonathan Jones.


Nishimura MT*, Monteiro F*, Dangl JL. Treasure your exceptions: unusual domains in immune receptors reveal host virulence targets. Cell 161(5):957-60 (2015). doi: 10.1016/j.cell.2015.05.017. PMID: 26000473

 Pérez-Rafael S, Monteiro F, Dallinger R, Atrian S, Palacios O, Capdevila M. Cantareus aspersus metallothionein metal binding abilities: the unspecific CaCd/CuMT isoform provides hints about the metal preference determinants in metallothioneins. Biochim Biophys Acta 1844(9):1694-707 (2014) doi: 10.1016/j.bbapap.2014.06.018. PMID: 24982030

 Monteiro F, Genin S, van Dijk I, Valls M. A luminescent reporter evidences active expression of Ralstonia solanacearum type III secretion system genes throughout plant infection. Microbiology 158, 2107-2116 (2012). doi:10.1099/mic.0.058610-0 PMID: 22609750

 Monteiro F, Solé M, van Dijk I, Valls M. A chromosomal insertion toolbox for promoter probing, mutant complementation and pathogenicity studies in Ralstonia solanacearum. Mol Plant Microbe Interact. 25(4), 557-68 (2012). doi: 10.1094/MPMI-07-11-0201. PMID: 22122329

Höckner M, Stefanon K, de Vaufleury A, Monteiro F, Pérez-Rafael S, Palacios O, Capdevila M, Atrian S, Dallinger R. Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus. Biometals 24, 1079-1092 (2011). doi:10.1007/s10534-011-9466-x. PMID: 21625890

Orihuela R, Monteiro F, Pagani A, Capdevila M & Atrian S. Evidence of Native Metal–S2−Metallothionein Complexes Confirmed by the Analysis of Cup1 Divalent-Metal-Ion Binding Properties. Chem. Eur. J. 16, 12363-12372 (2010). doi: 10.1002/chem.201001125. PMID: 20839184


* - Co-first authors