Kenan Distinguished Professor
The University of North Carolina at Chapel Hill
I am currently accepting applications for PhD students for scientific
exchange (J-1 visa status). Students who apply must have received a
scholarship from the Chinese Scholarship Council (CSC) to support their stay
in the US and to work in my laboratory for 6-24 months.
G-protein Signaling in Arabidopsis
My lab uses the model
organism, Arabidopsis, to understand signal transduction
mechanisms involving heterotrimeric G proteins. G proteins couple
signaling in a wide variety of biological contexts such as guard cell
physiology, multi-signal regulation of seed germination, root
development, stress responses, and auxin-regulated cell proliferation.
The Arabidopsis G protein pathway has several unique properties that
make it ideal for understanding general principles of G signaling in
eukaryotes (human health) as well as the plant-specific aspects that are
important for agriculture.
My lab uses a multidisciplinary
approach: Combinatorial Chemistries, Cell Biology, Protein Modeling,
Protein Chemistry, Biochemistry, Physiology, Pharmacology, and Genetics.
For example, we use biochemistry and protein modeling to determine the
requisite structure for the unique properties of plant G protein
elements. This includes obtaining crystal structures of worthwhile
proteins or protein domains. We also use sophisticated microscopies to
study how the spatial and temporal changes in G protein elements lead to
signaling or desensitization. We take genetic approaches using
Arabidopsis, including forward, reverse genetics and suppressor screens.
Applicants should apply to Dr. Alan Jones at: alan_jones at unc.edu
The University of North Carolina is located in Chapel Hill NC. The very
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