Systems Biology of G Protein Signaling The University of North Carolina, Schools of Medicine and Arts and Sciences |
Heterotrimeric G proteins serve as a signaling nexus in a myriad of normal and diseased cell states. Many extracellular signals (e.g. hormones, peptides, cytokines, lights) are perceived by 7-transmembrane receptors, often referred to as G protein coupled receptors (“GPCR” in figure at left), that stimulate the activation state of the cytoplasmic G protein complex. Interestingly, the majority of non-animal cells (protists, fungi, plants, amoeba and many others) bind GTP without the need for a GPCR. This recent discovery opens up new opportunities to find novel mechanisms that regulate G protein signaling. This project tightly integrates experimental investigations with mathematical modeling to discover and characterize novel signaling motifs that regulate pathway activity in the glucose sensing system of Arabidopsis. The project is a continuation of a well established collaboration between the labs of Drs. Alan Jones and Tim Elston (Fu, et al 2014 Cell 156:1084-1095). The ideal applicant will have experience with deterministic and stochastic modeling methods, and a willingness to learn the experimental techniques needed to test their mathematical models. Interested individuals should follow the “POSTDOCTORAL POSITION” link above or contact Tim Elston and Alan Jones. |
Trafficking of G Protein Signaling Elements The University of North Carolina, Schools of Medicine and Arts and Sciences |
Seeking a highly-motivated individuals to study in vivo spatial and
temporal changes in signaling elements of the heterotrimeric G-protein
pathway in Arabidopsis. Arabidopsis has become the most tractable model
system for study of the G-protein signal pathway in a multicellular
eukaryote. The candidate will have available a large set of genetic and
microscopy tools to address a novel signaling mechanism within a classic
signaling paradigm. The candidate must have experience in fluorescence
microscopies, including FRET analysis. Knowledge of or experience with
Arabidopsis is not necessary but useful. Excellent verbal, written, and
interpersonal skills are essential. The candidate must be fluent in
English. Salaries start at $37,000/yr plus benefits commensurate with
experience. Interested individuals should follow the “POSTDOCTORAL
POSITION” link above or contact Dr. Alan
Jones. The University of North Carolina is an Equal
Opportunity/Affirmative Action Employer
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