An
Evolutionarily Conserved Mediator of Plant Disease Resistance Gene Function Is Required for Normal Arabidopsis Development |
Developmental Cell, Vol. 2, 807817, June, 2002 |
Ben
F. Holt III, Douglas C. Boyes, Mats Ellerstrom, Nicholas Siefers, Aaron Wiig, Scott Kauffman, Murray R. Grant, and Jeffery L. Dangl |
Summary Plants recognize many pathogens through the action of a diverse family of proteins called disease resistance (R) genes. The Arabidopsis R gene RPM1 enodes resistance to specific Pseudomonas syringae strains. We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and -catenin-mediated signaling in animals. Reduction of Arabidopsis TIP49a (AtTIP49a) mRNA levels results in measurable increases of two R-dependent responses without constitutively activating defense responses, suggesting that AtTIP49a can act as a negative regulator of at least some R functions. Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development. |