Marc Nishimura

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       Ph.D., Biology, 2005. Stanford University

       B.A., 1994. Vassar College


Project Description:

I am interested in understanding how the translocated effector proteins of the plant pathogen, Pseudomonas syringae, interact with the plant host to both promote virulence and determine host range. To this end, we have generated a large collection of effector proteins that covers the diversity of 16 strains of Pseudomonas. Experiments are underway to identify interacting host targets, to determine in planta subcellular localization of effectors and to demonstrate their contribution to pathogen virulence.



Baltrus DA, Nishimura MT, Dougherty KM, Biswas S, Muhktar S, Vicente JG, Holub EB, Dangl J. The molecular basis of host specialization in bean pathovars of Pseudomonas syringae. Mol Plant Microbe Interact. 2012 Mar 14. [Epub ahead of print]

Bonardi V, Cherkis K, Nishimura MT, Dangl JL. A new eye on NLR proteins: focused on clarity or diffused by complexity? Curr Opin Immunol. 2012 Feb;24(1):41-50.

Wang Y, Nishimura MT, Zhao T, Tang D. ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis. Plant J. 2011 Oct;68(1):74-87.

Mukhtar MS, Carvunis AR, Dreze M, Epple P, Steinbrenner J, Moore J, Tasan M, Galli M, Hao T, Nishimura MT, Pevzner SJ, Donovan SE, Ghamsari L, Santhanam B, Romero V, Poulin MM, Gebreab F, Gutierrez BJ, Tam S, Monachello D, Boxem M, Harbort CJ, McDonald N, Gai L, Chen H, He Y; European Union Effectoromics Consortium, Vandenhaute J, Roth FP, Hill DE, Ecker JR, Vidal M, Beynon J, Braun P, Dangl JL. Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science. 2011 Jul 29;333(6042):596-601.

Baltrus DA*, Nishimura MT*, Romanchuk A, Chang JH, Mukhtar MS, Cherkis K, Roach J, Grant SR, Jones CD, Dangl JL. Dynamic evolution of pathogenicity revealed by sequencing and comparative genomics of 19 Pseudomonas syringae isolates. PLoS Pathog. 2011 Jul;7(7)

Nishimura MT, Dangl JL. Arabidopsis and the plant immune system. Plant J. 2010 Mar;61(6):1053-66.

Mukhtar MS, Nishimura MT, Dangl J. NPR1 in Plant Defense: It's Not over 'til It's Turned over. Cell. 2009 May 29;137(5):804-6

Reinhardt JA, Baltrus DA, Nishimura MT, Jeck WR, Jones CD, Dangl JL. De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae. Genome Res. 2009 Feb;19(2):294-305.

Vorwerk S, Schiff C, Santamaria M, Koh S, Nishimura M, Vogel J, Somerville C, Somerville S. EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana. BMC Plant Biol. 2007 Jul 6;7:35.

Nishimura MT*, Stein M*, Hou BH, Vogel JP, Edwards H, Somerville SC. Loss of a callose synthase results in salicylic acid-dependent disease resistance. Science. 2003 Aug 15;301(5635):969-72. PubMed PMID: 12920300.

Nishimura M, Somerville S. Plant biology. Resisting attack. Science. 2002 Mar 15;295(5562):2032-3. PubMed PMID: 11896264.

Somerville, S.C., Nishimura, M., Hughes, D., Wilson, I., and Vogel, J. 1998. Alternate methods of gene discovery -- the candidate gene approach and DNA microarrays. Pages 297-309 in: Cellular Integration of Signaling Pathways in Plant Development. NATO ASI Series, Vol. H104 (F. Lo Schiavo, R.L. Last, G. Morelli, and N.V. Raikhel, eds.). Springer-Verlag, Berlin.

Botella MA, Coleman MJ, Hughes DE, Nishimura MT, Jones JD, Somerville SC. Map positions of 47 Arabidopsis sequences with sequence similarity to disease resistance genes. Plant J. 1997 Nov;12(5):1197-211. PubMed PMID: 9418057.

(*, contributed equally)