Publications

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The Ahmed Lab

Luciana Leopold, Bree Heestand, Soobin Seong, Ludmilla Shtessel and Shawn Ahmed (2015). Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans. PNAS 112: E2667-2676.

Aisa Sakaguchi, Peter Sarkies, Matt Simon, Anna-Lisa Doebley, Leonard D. Goldstein, Ashley Hedges, Kohta Ikegami, Stacy M. Alvares, Liwei Yang, Jan R. LaRocque, Julie Hall, Eric A. Miska and Shawn Ahmed (2014). Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations. PNAS 111: E4323-4331.

Matt Simon, Peter Sarkies, Kohta Ikegami, Anna-Lisa Doebley, Leonard D. Goldstein, Jacinth Mitchell, Aisa Sakaguchi, Eric A. Miska and Shawn Ahmed (2014). Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants. Cell Reports 7: 1-12.

Stacy M. Alvares, Gaea A. McCaig, Ebony Y. Joyner, Bernard Lakowsk and Shawn Ahmed (2013). H3K4 demethylase activities repress proliferative and post-mitotic aging. Aging Cell 13: 245-253.

Ludmila Shtessel, Mia Lowden, Chen Cheng, Matt Simon, Kyle Wang and Shawn Ahmed (2013). Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways. G3 3: 305-313.

Alyson Ashe, Alexandra Sapetschnig, Eva-Maria Weick, Jacinth Mitchell, Marloes P. Bagijn, Amy C. Cording, Anna-Lisa Doebley, Leonard D. Goldstein, Nicolas J. Lehrbach, Jérémie Le Pen, Greta Pintacuda, Aisa Sakaguchi, Peter Sarkies, Shawn Ahmed* and Eric A. Miska* (2012). piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Cell 150: 88-99.
*equal contribution

Chen Cheng, Lumilla Shtessel, Megan Brady and Shawn Ahmed (2012). Caenorhabditis elegans POT-2 represses a mode of ALT with normal telomere lengths. PNAS 109: 7805-7810.

Mia Rochelle Lowden, Stephane Flibotte, Donald Moerman, and Shawn Ahmed (2011). DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions. Science 332: 468-471.

Ludmila Shtessel and Shawn Ahmed (2011). Telomere dysfunction in human bone marrow failure syndromes. Nucleus 2: 24-29.

Aymeric P. Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M.J. Lilley, Shawn Ahmed and Anton Gartner  (2010). The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. PLoS Genetics 6: e1001025.

Bettina Meier, Louise J. Barber, Yan Liu, Ludmila Shtessel, Simon J. Boulton, Anton Gartner and Shawn Ahmed (2009). The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in C. elegans. EMBO Journal doi:10.1038/emboj.2009.278.

Sebastien Greiss, Julie Hall, Shawn Ahmed and Anton Gartner (2008). C. elegans SIR-2.1 translocation is linked to a pro-apoptotic pathway parallel to cep-1/p53 during DNA damage induced apoptosis. Genes and Development 22: 2831-2842.

Mia Rochelle Lowden, Teresa Wei-ay Lee, Bettina Meier, Julie Hall and Shawn Ahmed (2008). End-joining at Caenorhabditis elegans telomeres. Genetics 180: 741-754.

Julie Boerckel, Dana Walker and Shawn Ahmed (2007).The RFC-clamp loader HPR-17 is required for telomere replication in C. elegans.Genetics 176: 703-709.

Shawn Ahmed (2006).Uncoupling of pathways that promote post-mitotic lifespan and apoptosis from replicative immortality of C. elegans germ cells.Aging Cell 5: 559-563.

Theresa Zucchero and Shawn Ahmed (2006).Genetics of proliferative aging.Experimental Gerontology 41: 992-1000.

Japser Harris, Mia Lowden, Iuval Clejan, Monika Tzoneva, James Thomas, Jonathan Hodgkin and Shawn Ahmed (2006). Mutator phenotype of C. elegans DNA damage checkpoint mutants. Genetics 174: 601-616.

Iuval Clejan, Julie Boerckel and Shawn Ahmed (2006). Developmental modulation of non-homologous end-joining in C. elegans. Genetics 173: 1301-1317.

Bettina Meier, Iuval Clejan, Yan Liu, Mia Lowden, Jonathan Hodgkin, and Shawn Ahmed (2006). trt-1 is the C. elegans catalytic subunit of telomerase. PLoS Genetics 2: e18.

Chris Smelick and Shawn Ahmed (2005). Achieving immortality in the C. elegans germline. Aging Research Reviews 4: 67-82.

Jacapo Novelli, Shawn Ahmed and Jonathan Hodgkin (2004). Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. Genetics 168: 1259-1273.

Shawn Ahmed, Arno Alpi, Michael O. Hengartner and Anton Gartner (2001). C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Current Biology 11: 1934-1944.

Bettina Meier and Shawn Ahmed (2001). Checkpoints: Meiotic chromosome pairing takes an unexpected twist. Current Biology 11: R865-R868.

Shawn Ahmed and Jonathan Hodgkin (2000). MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature 403: 159-164.

Anton Gartner, Stuart Milstein, Shawn Ahmed, Jonathan Hodgkin and Michael O. Hengartner (2000). A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans. Molecular Cell 5: 435-443.

Shawn Ahmed, Hong Sheng, Luming Niu and Eric Henderson (1998). Tetrahymena mutants with short telomeres. Genetics 150: 643-650.

Shawn Ahmed, Augustin Kintanar and Eric Henderson (1994). Human telomeric C-strand tetraplexes. Nature Structural Biology 1: 83-88.

Shawn Ahmed and Eric Henderson (1992). Formation of novel hairpin structures by telomeric C-strand oligonucleotides. Nucleic Acids Research 20: 507-511.